Rare Copy Number Variants Reveal Critical Cell Types and Periods of Brain Development in Neurodevelopmental Disorders
Overall, we showed that although NDDs are only diagnosed during childhood or adolescence, the actual effect of genetic mutations on embryonic progenitor cells or early neurons may be strongest during fetal brain development, which could program the cascade for subsequent developmental changes and, together with further postnatal dysfunction, impair brain function.
Authors
- Carl M. Sellgren (ORCID: https://orcid.org/0000-0001-9103-2785)
- Konstantin V. Khodosevich (ORCID: https://orcid.org/0000-0001-7232-5558)
- Navneet A. Vasistha (ORCID: https://orcid.org/0000-0002-6721-114X)
- Susmita Malwade (ORCID: https://orcid.org/0000-0002-6756-018X)
Institutions
- University of Copenhagen (DK)
- Stockholm County Council (SE)
- Karolinska Institutet (SE)
- Stockholm Health Care Services (SE)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100495
- Citations
- 4
- Primary Topic
- Genomic variations and chromosomal abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- Familjen Erling-Perssons Stiftelse
- Australian Government
- European Commission
- Lundbeckfonden
- Novo Nordisk
- Vetenskapsrådet
- Novo Nordisk Fonden
- H. Lundbeck A/S