Research Progress of Deep Cervical Lymphatic Vessel/Lymph Node-Venous Anastomosis in the Treatment of Alzheimer’s Disease

阿尔兹海默病是一种与年龄相关，导致认知和功能障碍的神经退行性疾病，其特征为特定的神经病理变化。尽管阿尔兹海默病的发病机制与生物标志物研究已经取得了巨大的进展，但阿尔兹海默病到目前为止仍是一个不治之症。目前阿尔兹海默病的主要治疗方式是对症支持治疗，但并不能延缓疾病的进展。随着“脑膜淋巴管”概念的提出以及人们对它的进一步研究，发现脑膜淋巴管最终汇集于颈深淋巴结。近年来，手术治疗作为一种潜在的创新治疗方案受到越来越多的关注。本文综述了颈深淋巴管/淋巴结–静脉吻合术在阿尔兹海默病治疗中的潜力与应用。Alzheimer’s disease is a central nervous system degenerative disease characterized by age-related cognitive decline and behavioral impairment. Despite significant progress in the pathogenesis and biomarker research of Alzheimer’s disease, it remains an incurable disease to date. At present, the main treatment for Alzheimer’s disease is symptomatic supportive treatment, but it cannot delay the progression of the disease. With the introduction of the concept of “meningeal lymphatic vessels” and further research, it has been found that meningeal lymphatic vessels ultimately converge in the deep cervical lymph nodes. In recent years, surgical treatment has gained increasing attention as a potential innovative therapeutic option. This article reviews the potential and application of deep cervical lymphatic vessel/lymph node-venous anastomosis in the treatment of Alzheimer’s disease.