Research Progress of Thymic Stromal Lymphopoietin and Cardiovascular Diseases

胸腺基质淋巴细胞生成素(TSLP)是一种多效性细胞因子，在免疫调节和炎症反应中发挥重要作用。近年来，越来越多的研究表明TSLP在心血管疾病(CVD)的发生发展中起着重要作用。TSLP通过调节炎症免疫反应参与动脉粥样硬化、冠状动脉粥样硬化性心脏病、心力衰竭、心肌纤维化等心血管疾病的病程进程。本文将综述TSLP在CVD中的最新研究进展，探讨其作为潜在治疗靶点的可能性。Thymic stromal lymphopoietin (TSLP), as a pleiotropic cytokine which plays a pivotal role in immune regulation and inflammatory responses. In recent years, accumulating evidence has demonstrated the significance of TSLP in the pathogenesis and progression of cardiovascular diseases (CVD). By regulating inflammatory immune response, TSLP participates in the pathological progression of atherosclerosis, coronary atherosclerotic heart disease, heart failure, hypertension, myocardial fibrosis and other CVD. This article reviews the latest research progress of TSLP in CVD, and evaluates the possibility of TSLP as a potential therapeutic target for cardiovascular disease.