Norcantharidin inhibits TOP2A expression via H3K27me3 mediated epigenetic regulation to alleviate the progression of hepatocellular carcinoma
Our findings establish that NCTD exerts anticancer effects in HCC through epigenetic silencing of TOP2A. This work not only elucidates a novel pharmacoepigenetic mechanism underlying NCTD's antitumor activity but also provides translational rationale for developing PRC2-targeted therapeutic strategies in HCC management.
Authors
- Xiu‐Ling Deng (ORCID: https://orcid.org/0000-0003-3908-6086)
- Yuehua Wang (ORCID: https://orcid.org/0000-0002-1941-4890)
- Ruibing Wu (ORCID: https://orcid.org/0009-0009-5985-7168)
- Changshan Wang (ORCID: https://orcid.org/0000-0002-6719-2444)
- Hailong Yuan (ORCID: https://orcid.org/0000-0002-4554-5579)
- Zhongzheng Zhou (ORCID: https://orcid.org/0000-0002-4462-7839)
- Xianggang Gou
- Xinran Wang (ORCID: https://orcid.org/0000-0002-3975-1667)
- Wenhuan Hou (ORCID: https://orcid.org/0000-0002-1731-399X)
- Haisheng Wang (ORCID: https://orcid.org/0009-0007-1064-3412)
- Jia Yan (ORCID: https://orcid.org/0000-0002-6203-0016)
Institutions
- Inner Mongolia University (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fphar.2025.1541298
- Citations
- 1
- Primary Topic
- Beetle Biology and Toxicology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94