Signaling of Mitogenic and Metabolic Activities by Fibroblast Growth Factors

Fibroblast growth factors are signaling molecules that play crucial roles in fundamental processes such as cell migration, proliferation, differentiation, angiogenesis, and cell survival. FGFs signal by forming a complex with tyrosine kinase FGF receptors and cofactors. It is well known that FGFs play diverse roles in different tissues and at different developmental stages due to factors such as receptors, specific FGFs, and environmental conditions such as temperature and pH. This review focuses on the actions of mitogenic and metabolic FGFs and their interactions with their receptors to trigger their designated functions.