TAp73 modulates proliferation and ferroptosis in mammary epithelial cells
<i>TAp73</i> acts as a dual regulator of epithelial cell fate by inhibiting proliferation and promoting ferroptosis. These findings reveal a novel role for <i>TAp73</i> in epithelial cell biology and suggest potential therapeutic targets for diseases involving epithelial cell death.
Authors
- Yilu Zhang (ORCID: https://orcid.org/0009-0000-2742-2922)
- Wenqiang Sun (ORCID: https://orcid.org/0000-0002-8589-639X)
- Bingfei Zhang
- Jiaqi Li (ORCID: https://orcid.org/0000-0001-9357-8511)
- Jiaqi Wen (ORCID: https://orcid.org/0000-0001-9723-4695)
- Le Chen (ORCID: https://orcid.org/0000-0003-2605-0834)
- Yong-Ping Yan (ORCID: https://orcid.org/0000-0001-9393-1530)
- Liping Mei (ORCID: https://orcid.org/0000-0003-4033-5852)
- Songjia Lai
- Hanjun Ren
Institutions
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fcell.2025.1532910
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00