Circ_0098181 binds PKM2 to attenuate liver fibrosis
In conclusion, circ_0098181 exerts a significant anti-fibrotic effect by binding PKM2 to repress its nuclear translocation and inhibiting hepatic inflammation, suggesting the promising therapeutic merit in liver cirrhosis.
Authors
- Ke-Gong Tao
- Hongsheng Zhan (ORCID: https://orcid.org/0000-0002-7749-8340)
- Xin Zeng (ORCID: https://orcid.org/0000-0002-4180-3366)
- Ling-Yan Cai (ORCID: https://orcid.org/0000-0002-9859-9095)
- Yuanyuan Luo (ORCID: https://orcid.org/0000-0002-3826-3637)
- Yaping Guan
- Yong Lin (ORCID: https://orcid.org/0000-0002-2653-7143)
- Chun-Yan Sun
Institutions
- Shanghai Changzheng Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fphar.2025.1517250
- Citations
- 1
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81