Escitalopram alters tryptophan metabolism, plasma lipopolysaccharide, and the inferred functional potential of the gut microbiome in deer mice showing compulsive-like rigidity
These findings support the role of altered serotonergic mechanisms, inflammatory processes, and gut microbiome involvement in compulsive-like behavioural rigidity. Our results also highlight the importance of gut-brain crosstalk mechanisms at the level of TRP metabolism in the spontaneous development of such behaviour.
Authors
- Gerard Clarke (ORCID: https://orcid.org/0000-0001-9771-3979)
- Thomaz F. S. Bastiaanssen (ORCID: https://orcid.org/0000-0001-6891-734X)
- Anna‐Ursula Happel (ORCID: https://orcid.org/0000-0003-3658-8638)
- De Wet Wolmarans (ORCID: https://orcid.org/0000-0002-3440-4869)
- Benjamín Valderrama (ORCID: https://orcid.org/0000-0002-4740-8965)
- Brian H. Harvey (ORCID: https://orcid.org/0000-0002-9864-7894)
- Heather B. Jaspan (ORCID: https://orcid.org/0000-0002-0745-6073)
- Dan Joseph Stein (ORCID: https://orcid.org/0000-0001-7218-7810)
- John F. Cryan (ORCID: https://orcid.org/0000-0001-5887-2723)
- Rencia van der Sluis (ORCID: https://orcid.org/0000-0003-3463-1700)
- Larissa Karsten
Institutions
- Center for Infectious Disease Research (US)
- Barwon Health (AU)
- Deakin University (AU)
- University of Cape Town (ZA)
- University of Washington (US)
- University College Cork (IE)
- North-West University (ZA)
- Seattle Children's Hospital (US)
- APC Microbiome Institute (IE)
Publication Details
- Journal
- Acta Neuropsychiatrica
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1017/neu.2025.16
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- University of Cambridge