GPR83 protects cochlear hair cells against ibrutinib-induced hearing loss through AKT signaling pathways
These findings confirm ibrutinib's ototoxicity and highlight the protective role of GPR83 in ibrutinib-induced hearing loss, supporting future clinical investigations into Z-VAD-FMK and GPR83 as interventions for ibrutinib or other chemotherapeutic drug-induced ototoxicity.
Authors
- Wei Cao (ORCID: https://orcid.org/0000-0002-8546-6090)
- Yan Lin (ORCID: https://orcid.org/0000-0001-5779-1817)
- Yanghua Tian (ORCID: https://orcid.org/0000-0001-5038-0599)
- Yongjie Wei
- Jianming Yang (ORCID: https://orcid.org/0000-0002-2996-399X)
- Yun Xiao (ORCID: https://orcid.org/0000-0001-8514-8175)
- Yanling Zhang (ORCID: https://orcid.org/0000-0003-4135-9696)
- Nan Cheng
- Yongjun Zhu (ORCID: https://orcid.org/0000-0002-3630-3893)
- Yuhua Zhang
Institutions
- Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fmed.2025.1579285
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation