Anti–Peptidylarginine Deiminase 4 Autoantibodies Derived From Patients With Rheumatoid Arthritis Exert Pathogenic Effects by Activating Monocytes and Exacerbating Inflammatory Arthritis
Our findings suggest a model in which anti-PAD4 antibody binding to monocytes triggers an inflammatory cascade that promotes immune cell recruitment to the joint and T cell activation, culminating in synovial fibroblast activation and the development of more severe arthritis.
Authors
- Megan Kay Wood (ORCID: https://orcid.org/0000-0001-5176-8210)
- Mekha A. Thomas (ORCID: https://orcid.org/0000-0002-5169-6568)
- Camille M. Jaime
- Stuart C. Ray (ORCID: https://orcid.org/0000-0002-1051-7260)
- Felipe Andrade (ORCID: https://orcid.org/0000-0003-3415-0704)
- Catherine A. Foss (ORCID: https://orcid.org/0000-0001-8870-5993)
- William Bracamonte‐Baran
- Jing Shi (ORCID: https://orcid.org/0000-0002-1172-3226)
- Erika Darrah (ORCID: https://orcid.org/0000-0003-1119-0279)
- Taejoon Won (ORCID: https://orcid.org/0000-0001-5968-2016)
- Pooja Naik (ORCID: https://orcid.org/0000-0002-2753-7129)
- Daniela Čiháková (ORCID: https://orcid.org/0000-0002-8713-2860)
- Wonyoung Jo (ORCID: https://orcid.org/0009-0002-2392-900X)
- Hong Wang (ORCID: https://orcid.org/0000-0001-6258-4070)
- Monica V. Talor (ORCID: https://orcid.org/0000-0002-8275-5698)
Institutions
- Johns Hopkins University (US)
- University of Illinois Urbana-Champaign (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1002/art.43168
- Citations
- 5
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- American Heart Association
- Bristol-Myers Squibb
- Pfizer
- AstraZeneca
- Celgene
- Johns Hopkins University
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Arthritis and Musculoskeletal and Skin Diseases