Regulation of Chondrocyte Metabolism and Osteoarthritis Development by Sirt5 Through Protein Lysine Malonylation
We found that Sirt5-mediated MaK is an important regulator of chondrocyte cellular metabolism, and dysregulation of Sirt5-MaK could be an important mechanism underlying aging- and obesity-associated OA development.
Authors
- Jacob Rose
- Birgit Schilling (ORCID: https://orcid.org/0000-0001-9907-2749)
- Craig R. G. Willis
- Joanna Bons (ORCID: https://orcid.org/0000-0002-1110-4193)
- Shivakumar R. Veerabhadraiah (ORCID: https://orcid.org/0000-0002-9353-4591)
- Shouan Zhu (ORCID: https://orcid.org/0000-0002-4973-1504)
- Anupama Binoy (ORCID: https://orcid.org/0000-0001-6425-9570)
- Michael J. Jurynec (ORCID: https://orcid.org/0000-0003-2702-9164)
- Huanhuan Liu (ORCID: https://orcid.org/0000-0003-1790-3073)
- Siqi Ren (ORCID: https://orcid.org/0000-0002-1734-6230)
- T. Martino
- Anna E. Miller
Institutions
- Buck Institute for Research on Aging (US)
- University of Bradford (GB)
- University of Utah (US)
- University of Exeter (GB)
- Osteopathic Heritage Foundation (US)
- Ohio University (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1002/art.43164
- Citations
- 7
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 8.57