GLP-1RAs regulate lipid metabolism and induce autophagy through AMPK/SIRT1 pathway to improve NAFLD
GLP-1RAs may lower hepatic steatosis by regulating lipid metabolism and enhancing autophagy in an AMPK/SIRT1-dependent manner, providing a new target for the treatment of NAFLD.
Authors
- Yang Cao (ORCID: https://orcid.org/0000-0002-0058-614X)
- Chun-Yan Niu
- Hongqin Yue (ORCID: https://orcid.org/0000-0002-4159-4963)
- Qiang Zhang (ORCID: https://orcid.org/0000-0002-5923-2696)
- Jingyuan Wang (ORCID: https://orcid.org/0000-0001-6897-4387)
- Xiaomin Hu (ORCID: https://orcid.org/0000-0002-5921-1051)
- Wei Lu (ORCID: https://orcid.org/0000-0001-6614-8727)
Institutions
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Lishui City People's Hospital (CN)
- Yancheng Third People's Hospital (CN)
Publication Details
- Journal
- Prostaglandins & Other Lipid Mediators
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1016/j.prostaglandins.2025.106987
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 6.77