Baseline lipid profile is associated with adverse outcomes in adults with coronary artery disease and obstructive sleep apnea despite lipid-lowering drugs and CPAP treatment: A secondary analysis of the RICCADSA cohort

OSA patients had higher TG and lower HDL levels than no-OSA patients whereas LDL levels were similar at baseline. There were no significant within-group differences in the CPAP group, no-CPAP group and no-OSA group regarding the lipid levels after one year. Undesired LDL levels at baseline predicted MACCEs med Hazard Ratio 2.18 (%95 CI 1.03-4.60; p = 0.04.) CONCLUSIONS: Most of the RICCADSA cohort had undesired LDL levels at baseline despite statin treatment, and CPAP had no additional lipid lowering effect after one year, suggesting that a more aggressive lipid lowering therapy as well as a more effective OSA treatment in addition to lifestyle changes should be targeted in the management of CAD patients with concomitant OSA.