Development of a multi-epitope vaccine from outer membrane proteins and identification of novel drug targets against Francisella tularensis: an In Silico approach
This study designed an MEV and proposed novel drug targets to address tularemia, offering broad protection against various <i>F. tularensis</i> strains. MEV, with favorable physicochemical properties, showed strong potential through molecular docking and dynamic simulations. Immune simulations suggest that it may elicit robust responses against pathogens. The identification of novel drug targets can lead to the discovery of new antimicrobial agents. However, further <i>in vitro</i> and <i>in vivo</i> studies are required to validate their efficacy and capability.
Authors
- Mohammad Reza Asadi Karam (ORCID: https://orcid.org/0000-0003-1000-9116)
- Farzad Badmasti (ORCID: https://orcid.org/0000-0003-3502-147X)
- Amir Salek Farrokhi (ORCID: https://orcid.org/0000-0001-5417-8697)
- Safoura Moradkasani (ORCID: https://orcid.org/0000-0002-9934-4262)
- Mohsen Chiani (ORCID: https://orcid.org/0000-0001-6413-8752)
- Saber Esmaeili (ORCID: https://orcid.org/0000-0003-1920-1737)
- Ehsan Mostafavi (ORCID: https://orcid.org/0000-0002-1997-517X)
- Behzad Shahbazi (ORCID: https://orcid.org/0000-0002-0903-2960)
Institutions
- Pasteur Institute of Iran (IR)
- Semnan University of Medical Sciences (IR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1479862
- Citations
- 7
- Primary Topic
- Bacillus and Francisella bacterial research
- Type
- article
- Field-Weighted Citation Impact
- 5.64