TOPIC: PROPOFOL AND PROPERTIES, MECHANISMS OF ACTION, ADMINISTRATION TECHNIQUES, MONITORING AND TOXICITY

As the part of the development of a model for the study of propofol, we have investigated the propofol properties, administration techniques, monitoring & adverse effects. A systematic search for any type of report published and unpublished, was made to review the evidence that propofol increases the risk of hypotension, bradycardia, hypertriglyceridemia, apnea, myocardial depression etc. So, its safe use is necessary to drive optimal patient outcomes. We reviewed some published journals in 2009, there are 97 cases of propofol associated deaths also 108 publications documenting that showed 168 cases of propofol infusion syndrome. The study found that nearly 60% deaths from accidental overdose of propofol than remaining cases were interlinked to drug interaction or any other factors that leads death. This activity outlines the appropriate use of propofol based on categorized patients, so anesthesiologist or any other anesthesia practioners can direct patient anesthesia, where it is indicated as part of the interprofessional team and improving patient outcomes.