Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations
TPL inhibits RA-FLS in motility by regulating actin cytoskeleton remodeling through action on the RhoA/Rho-associated kinase signaling pathway.
Authors
- Masataka Sunagawa (ORCID: https://orcid.org/0000-0001-7621-2024)
- Nan Xu (ORCID: https://orcid.org/0000-0003-1212-7773)
- Jiacheng Shen (ORCID: https://orcid.org/0000-0001-8615-071X)
- Zewen Chu (ORCID: https://orcid.org/0000-0002-8110-5298)
- Haibo Wang (ORCID: https://orcid.org/0000-0002-2219-522X)
- Yanqing Liu (ORCID: https://orcid.org/0000-0001-6812-2811)
- Guoqing Li (ORCID: https://orcid.org/0000-0002-6557-1301)
- Dan Li (ORCID: https://orcid.org/0000-0001-5904-871X)
- Miao Zhu (ORCID: https://orcid.org/0000-0001-7295-6384)
- Yuxuan Fang
- Hongyi Chen (ORCID: https://orcid.org/0009-0003-2099-3855)
Institutions
- SHOWA Medical University (JP)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fphar.2025.1545514
- Citations
- 4
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.53
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangsu Province
- Yangzhou University