Astragaloside IV alleviated bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and fecal metabolism
This study provides new insights into the use of AS-IV for treating PMOP, highlighting the gut microbiota and its metabolites as key regulatory factors in AS-IV's therapeutic effects.
Authors
- Huichao Wang (ORCID: https://orcid.org/0000-0003-3584-090X)
- Guangnan Chen (ORCID: https://orcid.org/0000-0003-0648-7780)
- Zhongyue Huang (ORCID: https://orcid.org/0000-0002-7928-5568)
- Huijie Gu (ORCID: https://orcid.org/0000-0002-6044-4979)
- Yang Li (ORCID: https://orcid.org/0000-0002-7016-2246)
- Youwen Liu (ORCID: https://orcid.org/0000-0002-8616-1029)
- Yujing Cao (ORCID: https://orcid.org/0009-0003-6922-378X)
Institutions
- Henan University of Traditional Chinese Medicine (CN)
- Fudan University (CN)
- Minhang District Central Hospital (CN)
- Zhengzhou City Hospital (CN)
- First Affiliated Hospital of Henan University (CN)
- Luoyang Orthopedic-Traumatological Hospital of Henan Province (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fphar.2025.1548491
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shanghai