The Shengmai San Exerts Therapeutic Effects on Type 2 Diabetes by Modulating the PI3K/AKT/GSK3B Signaling Pathway
SMS can help cure T2DM mellitus by regulating the PI3K/AKT/GSK3B pathway, improving islet tissue injury, reducing oxidative stress, and easing lipid metabolism issues. This study not only revealed the unique therapeutic mechanism of SMS by regulating the PI3K/AKT/GSK3β signaling pathway, but also provided new theoretical support for multi-target and personalized treatment of diabetes. Its novelty lies in the first exploration of the mechanism of action of traditional Chinese medicine prescriptions through the lens of modern molecular biology, emphasizing the potential of natural medicines in diabetes treatment.
Authors
- Hua Shang (ORCID: https://orcid.org/0000-0003-0998-0159)
- Lu Liu (ORCID: https://orcid.org/0000-0003-2683-7215)
- Yifei Wang
- Yue Qi (ORCID: https://orcid.org/0000-0002-3944-1140)
- Dao-Ran Pang
- Yan Gao
- Tianyu Wang
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Diabetes Metabolic Syndrome and Obesity
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dmso.s507953
- Citations
- 5
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 7.79