Colitis as a clinical manifestation of disseminated histoplasmosis in HIV-positive patient: a case report

Introduction: Disseminated histoplasmosis is a systemic fungal infection resulting from co-infection in severely immunosuppressed patients, such as those with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome.Case report: In this case report, a 49-year-old female HIV-positive patient, with complaints of black stool with fresh blood since two months was presented.Hemorrhoidectomy, followed by colonoscopy and biopsy were performed, confirming histoplasmosis infection diagnosis. Conclusions:The spectrum of clinical manifestations of disseminated histoplasmosis in HIV-infected patients are non-specific.Most disseminated histoplasmosis patients suffer from gastrointestinal problems.Anti-fungal therapy in histoplasmosis shows a good clinical response.