PCSK9 Regulates Cardiac Mitochondrial Cholesterol by Promoting TSPO Degradation
These findings indicate that PCSK9 regulates mitochondrial cholesterol levels by modulating the TSPO degradation in the heart. Modulation of mitochondrial cholesterol by targeting TSPO may be a promising therapeutic approach for heart failure.
Authors
- Frank Lezoualc’h (ORCID: https://orcid.org/0000-0001-5239-6017)
- Marion Laudette (ORCID: https://orcid.org/0000-0002-3431-9103)
- J. G. Smith (ORCID: https://orcid.org/0000-0001-6285-9935)
- Malin Lindbom
- Mathieu Cinato (ORCID: https://orcid.org/0000-0002-8490-4335)
- Azra Miljanovic (ORCID: https://orcid.org/0000-0003-0290-5711)
- Jan Borén (ORCID: https://orcid.org/0000-0003-0786-8091)
- Malin Levin (ORCID: https://orcid.org/0000-0003-1069-5275)
- Rosie Perkins (ORCID: https://orcid.org/0000-0003-2447-3286)
- Kristina Skålén (ORCID: https://orcid.org/0009-0003-5693-4339)
- Per‐Olof Bergh (ORCID: https://orcid.org/0000-0001-9993-6965)
- Muhammad Arif (ORCID: https://orcid.org/0000-0003-2261-0881)
- Tomasz Czuba (ORCID: https://orcid.org/0009-0001-0232-0425)
Institutions
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Sahlgrenska University Hospital (SE)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- KTH Royal Institute of Technology (SE)
- University of Gothenburg (SE)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1161/circresaha.124.325629
- Citations
- 4
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.22