Impact of Monoclonal Antibody Aggregates on Effector Function Characterization
Monoclonal antibody aggregation can impact FcγR binding for avidity-based binding formats. Even at low levels of antibody aggregation, FcγRII binding increases substantially.
Authors
- Matthew Clemens
- Wendy J. Walton
- Joseph J. Wilson
- Beth M. Harvey (ORCID: https://orcid.org/0000-0002-9291-5640)
- Yingmei Gu
- Sujuan Zhang (ORCID: https://orcid.org/0000-0003-4237-947X)
Institutions
- Eli Lilly (United States) (US)
Publication Details
- Journal
- Antibodies
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3390/antib14020031
- Citations
- 1
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Eli Lilly and Company