Deficiency of MTAP Is Frequent and Mostly Homogeneous in Pancreatic Ductal Adenocarcinomas
MTAP expression loss is frequent, caused by homozygous deletion, and mostly homogeneous in pancreatic ductal adenocarcinomas. Considering also their aggressive clinical behavior, pancreatic adenocarcinomas may represent an ideal cancer type for studying new drugs targeting MTAP-deficient cancer cells in clinical trials.
Authors
- Thilo Hackert (ORCID: https://orcid.org/0000-0002-7012-1196)
- Lukas Bubendorf (ORCID: https://orcid.org/0000-0001-5970-1803)
- Katharina Möller (ORCID: https://orcid.org/0000-0002-9739-4274)
- Maximilian Lennartz (ORCID: https://orcid.org/0000-0002-1572-8200)
- Guido Sauter (ORCID: https://orcid.org/0000-0002-9024-4978)
- Stefan Steurer (ORCID: https://orcid.org/0000-0002-7199-3615)
- Natalia Gorbokon (ORCID: https://orcid.org/0009-0001-6680-8788)
- Matthias S. Matter (ORCID: https://orcid.org/0000-0002-2005-5266)
- Sarah Jane Pauline Minner (ORCID: https://orcid.org/0000-0003-0765-3568)
- Viktor Reiswich
- Frank Jacobsen (ORCID: https://orcid.org/0009-0009-8047-580X)
- Waldemar Wilczak (ORCID: https://orcid.org/0009-0000-8438-9110)
- Florian Viehweger
- Faik G. Uzunoǧlu (ORCID: https://orcid.org/0000-0002-6890-4829)
- Till Sebastian Clauditz (ORCID: https://orcid.org/0000-0002-4257-856X)
- Morton Freytag (ORCID: https://orcid.org/0009-0001-3841-444X)
- Ronald Simon (ORCID: https://orcid.org/0000-0003-0158-4258)
- Martina Kluth (ORCID: https://orcid.org/0000-0003-4782-4616)
- Nina Schraps (ORCID: https://orcid.org/0009-0001-3056-2974)
- Katharina Teljuk
Institutions
- Universität Hamburg (DE)
- University Hospital of Basel (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- Pathologie Hamburg-West (DE)
Publication Details
- Journal
- Cancers
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3390/cancers17071205
- Citations
- 6
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 4.84