From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism Avoidance

The sublingual tablets of the solubility-enhanced HP-β-CD-AVA inclusion complex represent a promising strategy to improve AVA bioavailability and bypass the first-pass effect. Furthermore, their extended activity offers potential clinical benefits, particularly for ED patients, such as ease of administration and reduced side effects.

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Publication Details

Journal
Drug Design Development and Therapy
Published
2025-04-01
DOI
https://doi.org/10.2147/dddt.s504291
Primary Topic
Pharmacological Effects and Toxicity Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism Avoidance

Khalid M. El‐Say, Tarek A. Ahmed, Turky Omar Asar, Hossam S. El‐Sawy et al.
Drug Design Development and Therapy
Pharmacological Effects and Toxicity Studies
article

From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism Avoidance

Khalid M. El‐Say, Tarek A. Ahmed, Turky Omar Asar, Hossam S. El‐Sawy, Omar D. Al-hejaili, Abdelsattar M. Omar, Fathy I. Abd-Allah
article en

Abstract

The sublingual tablets of the solubility-enhanced HP-β-CD-AVA inclusion complex represent a promising strategy to improve AVA bioavailability and bypass the first-pass effect. Furthermore, their extended activity offers potential clinical benefits, particularly for ED patients, such as ease of administration and reduced side effects.

Drug Design Development and TherapyVol. Volume 19
Al-Azhar University (EG), King Abdulaziz University (SA), University of Wasit (IQ), University of Jeddah (SA), Egyptian Russian University (EG)
Zero hunger
Openalex Percentile: Top 92%
Pharmacological Effects and Toxicity Studies
DOIOpen Access PDFOpenAlex
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From Oral to Sublingual: A Redefined Avanafil Tablet with a Breakthrough in Bioavailability and First-Pass Metabolism Avoidance — Khalid M. El‐Say, Tarek A. Ahmed, et al. · Drug Design Development and Therapy (2025) | TGRS Research Map | TGRS