Wavefront sensing technologies for bioimaging

The Wavefront Sensing (WFS) element plays a crucial role in Adaptive Optics (AO) systems, which was originally developed and integrated in ground-based telescopes to evaluate atmospheric distortions. In recent decades, various WFS technologies have been applied across different fields from astronomy to microscopy, especially for medical imaging. In this paper, we present two innovative WFS technologies: the so-called phase crossed-sine WFS and phase-diversity WFS. These novel approaches have undergone rigorous experimental validation, with results consistently confirming their high performance across various controlled conditions and applications in metrology. The phase-diversity WFS technology has also been successfully adapted for use in bioimaging applications. A simultaneous multiplane imaging system based on a Quadratically Distorted (QD) grating has been established for real-time 3D imaging of fast moving biospecimens, advancing the capabilities of non-invasive bioimaging techniques.

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Published
2025-04-02
DOI
https://doi.org/10.1117/12.3046830
Primary Topic
Advanced Fluorescence Microscopy Techniques
Type
article
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article

Wavefront sensing technologies for bioimaging

Feng Yun Yan, Yuewei Liu, Zhengkun Liu, A. Spang et al.
Advanced Fluorescence Microscopy Techniques
article

Wavefront sensing technologies for bioimaging

Feng Yun Yan, Yuewei Liu, Zhengkun Liu, A. Spang, Wolfgang Schreiber, Monique Frain, François Hénault, A. Ortiz Velasquez, Philippe Gain, Jean-Jacques Correia, Gilles Thuret
article en

Abstract

The Wavefront Sensing (WFS) element plays a crucial role in Adaptive Optics (AO) systems, which was originally developed and integrated in ground-based telescopes to evaluate atmospheric distortions. In recent decades, various WFS technologies have been applied across different fields from astronomy to microscopy, especially for medical imaging. In this paper, we present two innovative WFS technologies: the so-called phase crossed-sine WFS and phase-diversity WFS. These novel approaches have undergone rigorous experimental validation, with results consistently confirming their high performance across various controlled conditions and applications in metrology. The phase-diversity WFS technology has also been successfully adapted for use in bioimaging applications. A simultaneous multiplane imaging system based on a Quadratically Distorted (QD) grating has been established for real-time 3D imaging of fast moving biospecimens, advancing the capabilities of non-invasive bioimaging techniques.

Nikon (United States) (US), University of Science and Technology of China (CN), Centre National de la Recherche Scientifique (FR), Université Paris Cité (FR), Institut de Planétologie et d'Astrophysique de Grenoble (FR), Laboratoire Matière et Systèmes Complexes (FR), Heinz Optical Engineering (United States) (US), Osservatorio di Astrofisica e Scienza dello Spazio, Lanzhou University (CN), Université Jean Monnet (FR), National Institute for Astrophysics (IT), Université Grenoble Alpes (FR)
Openalex Percentile: Top 94%
Advanced Fluorescence Microscopy Techniques
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