A temperature-responsive PLA-based nanosponge as a novel nanoadjuvant and efficient delivery carrier of Ag85B for effective vaccine against Mycobacterium tuberculosis
Ag85B@aPNS is a viable candidate for TB vaccination, showing potential as both a standalone vaccine and a BCG-booster. Its ability to enhance immunogenicity and provide protection highlights its promise in addressing the limitations of current TB vaccines.
Authors
- Sang‐Jun Ha (ORCID: https://orcid.org/0000-0002-1192-6031)
- Hyeryeon Oh (ORCID: https://orcid.org/0009-0006-4391-3346)
- Eunkyung Shin (ORCID: https://orcid.org/0009-0001-1525-2396)
- Jin-Seung Yun
- Won Il Choi (ORCID: https://orcid.org/0000-0002-8835-4940)
- Young-Ran Lee (ORCID: https://orcid.org/0000-0001-8696-5513)
- Dokeun Kim
- Yong Woo Jung (ORCID: https://orcid.org/0000-0002-5599-0553)
- Panmo Son (ORCID: https://orcid.org/0009-0000-0311-5194)
- Sunghyun Kim (ORCID: https://orcid.org/0000-0002-8725-4200)
- Jin Sil Lee
- Soo-Min Kim (ORCID: https://orcid.org/0000-0003-4834-9941)
- Hye-Sook Jeong (ORCID: https://orcid.org/0000-0003-2027-006X)
- S. C. Jeong
Institutions
- Seoul National University (KR)
- Yonsei University (KR)
- Korea University (KR)
- Gwangju Institute of Science and Technology (KR)
- Korea National Institute of Health (KR)
- Korea Institute of Ceramic Engineering and Technology (KR)
- Daegu-Gyeongbuk Medical Innovation Foundation (KR)
- Hanyang University (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s12964-025-02105-2
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Institute of Ceramic Engineering and Technology
- Korea National Institute of Health