Paritaprevir as a pan-antiviral against different flaviviruses
It is found that out of the 5 drugs, Ritonavir and Paritaprevir bind to the NS2B-NS3 protease of the ZIKV strongly with the Gibbs binding free energies (∆G<sub>bind</sub>) of -17.44±3.18 kcal/mol and -14.25±3.11 kcal/mol respectively. Remarkably, Ritonavir binds to the ZIKV Protease about 12 kcal/mol more strongly compared to its binding to the HIV protease. It is further found that Paritaprevir binds to DENV and WNV proteases as strongly as it binds to the ZIKV protease. Hence it is proposed that Paritaprevir may act as a potent pan-antiviral against the Zika, West Nile, and Dengue viral diseases.
Authors
- Rajendra Prasad Hubraj Yadav (ORCID: https://orcid.org/0000-0002-0398-1313)
- N. R. Jena (ORCID: https://orcid.org/0000-0002-5838-5164)
Institutions
- Indian Institute of Information Technology Design and Manufacturing Jabalpur (IN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fmolb.2025.1524951
- Citations
- 3
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 5.64