Selective toxicity of ascorbic acid and hydrogen peroxide on human tenon cells without harming scleral cells in vitro: A possible alternative to non-selective mitomycin C?
Unlike MMC, Ascorbic acid and hydrogen peroxide exhibit selective cytotoxicity towards Tenon fibroblasts, which may provide a safer, more targeted approach for preventing fibrosis in glaucoma surgery. Additional in vivo studies are needed to explore the clinical applicability of these findings.
Authors
- Carsten Framme (ORCID: https://orcid.org/0000-0001-8685-176X)
- Jan Tode (ORCID: https://orcid.org/0000-0003-2422-532X)
- Heiko Fuchs (ORCID: https://orcid.org/0000-0001-9142-4084)
- Amelie Pielen (ORCID: https://orcid.org/0000-0001-9401-2501)
- Roland Meister
- Yuqing Huang (ORCID: https://orcid.org/0000-0002-3182-1798)
- Bernd Junker (ORCID: https://orcid.org/0000-0002-5574-3309)
- Xiaonan Hu
- Martin Bartram
Institutions
- Medizinische Hochschule Hannover (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1371/journal.pone.0320558
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Wirtschaft und Energie