DNA lesions piece together impossible trees
DNA lesions can persist through multiple cell cycles, resulting in mutational strand asymmetry, multiallelic variation, and somatic mosaicism. But for how long do these lesions persist? Recent work from Spencer Chapman et al. shows that they can last for months to years, even arising from endogenous exposures in utero.
Authors
- Sarah J. Aitken (ORCID: https://orcid.org/0000-0002-1897-4140)
- Claudia Arnedo-Pac (ORCID: https://orcid.org/0000-0002-2037-8487)
Institutions
- University of Cambridge (GB)
- Yale University (US)
- Medical Research Council (GB)
Publication Details
- Journal
- Trends in Genetics
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.tig.2025.03.002
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research UK
- Medical Research Council