Cyclic Diphenylchloronium-Salt-Triggered Coupling of Sulfides with Nucleophiles: Modular Assembly of Pharmaceuticals

We report a novel coupling strategy enabled by cyclic diphenylchloronium salt that facilitates reactions between sulfides and diverse nucleophiles, including oxygen- and nitrogen-based species. The methodology efficiently produces structurally varied valuable compounds, including carbamates, carboxylic esters, aryl ethers, and alkylated amines, under mild, operationally simple conditions. The protocol's synthetic utility was highlighted through modular preparation of five important drugs and five structural analogues, demonstrating significant potential for drug discovery applications.