Photocatalytic Radical Cascade Cyclization of <i>N</i>-(<i>o</i>-Cyanobiaryl)acrylamides with Sulfonyl Chlorides
A photoredox-catalyzed radical cascade cyclization of <i>N</i>-(<i>o</i>-cyanobiaryl)acrylamides with sulfonyl chlorides for the construction of sulfonyl-containing pyrido[4,3,2-<i>gh</i>]phenanthridines has been disclosed. The developed synthetic tool tolerates a broad range of sulfonyl chlorides to undergo a cascade sequence, including sulfonyl radical addition, nitrile insertion, and cyclization.
Authors
- Min Gao (ORCID: https://orcid.org/0000-0003-0127-7477)
- Jian-Hong Fan (ORCID: https://orcid.org/0009-0009-0136-8281)
- Yu Liu (ORCID: https://orcid.org/0000-0003-4555-8238)
Institutions
- Hunan Institute of Science and Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1021/acs.joc.5c00288
- Citations
- 7
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province