Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours
Among Chinese patients with mainly mild posterior circulation stroke who did not receive thrombectomy, alteplase administered 4.5 to 24 hours after stroke onset resulted in a higher frequency of functional independence at 90 days than standard medical care. (Funded by the National Natural Science Foundation of China; EXPECTS ClinicalTrials.gov number, NCT05429476.).
Authors
- Maarten G. Lansberg (ORCID: https://orcid.org/0000-0002-3545-6927)
- C. Z. Yuan (ORCID: https://orcid.org/0000-0002-1652-6686)
- Shenqiang Yan (ORCID: https://orcid.org/0000-0001-6425-0672)
- Fujian Chen (ORCID: https://orcid.org/0000-0002-8606-3648)
- Yu Han (ORCID: https://orcid.org/0000-0002-3369-7655)
- Xuting Zhang (ORCID: https://orcid.org/0000-0002-1522-4694)
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Wansi Zhong (ORCID: https://orcid.org/0000-0002-4775-7778)
- Lingqun Mao (ORCID: https://orcid.org/0009-0001-6554-8654)
- Min Lou (ORCID: https://orcid.org/0000-0002-6627-064X)
- Hui Chen (ORCID: https://orcid.org/0000-0003-2866-7811)
- Yaode He (ORCID: https://orcid.org/0000-0003-3616-6769)
- Bruce C.V. Campbell (ORCID: https://orcid.org/0000-0003-3632-9433)
- Xiaona Wang (ORCID: https://orcid.org/0000-0001-8710-1688)
- Yuhui Huang (ORCID: https://orcid.org/0000-0002-8575-7285)
- Huan Zhou (ORCID: https://orcid.org/0000-0003-0546-6611)
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-5368-7596)
- Kun Chen (ORCID: https://orcid.org/0000-0003-1162-6896)
- Bing Zhang (ORCID: https://orcid.org/0000-0001-6391-5142)
- Jianbing Wang (ORCID: https://orcid.org/0000-0002-5571-2174)
- Yi Chen (ORCID: https://orcid.org/0000-0002-3054-0839)
- Ying Zhou (ORCID: https://orcid.org/0000-0003-1465-4569)
- Hongfang Chen (ORCID: https://orcid.org/0000-0002-0706-9559)
Institutions
- The Royal Melbourne Hospital (AU)
- Harvard University (US)
- University of California, Los Angeles (US)
- The University of Melbourne (AU)
- Jiaxing University (CN)
- Huzhou Central Hospital (CN)
- Taizhou Central Hospital (CN)
- Wenzhou City People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
- Stanford University (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1056/nejmoa2413344
- Citations
- 38
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 51.46
Funders
- National Natural Science Foundation of China