Elevated expression of microRNA-155, microRNA-383, and microRNA-9 in Iranian patients with polycystic ovary syndrome
Our findings suggest that miR-155, miR-383, and miR-9 are significantly upregulated in Iranian PCOS patients, highlighting their potential as biomarkers or therapeutic targets. However, no significant associations were found between the investigated SNPs and PCOS risk. Future studies with larger, multi-ethnic cohorts are warranted to validate these findings and explore the molecular mechanisms underlying the roles of these miRNAs in PCOS pathophysiology.
Authors
- Hamed Afkhami (ORCID: https://orcid.org/0000-0002-1110-6447)
- Kambiz Roshanaei
- Nasrin Heidarieh (ORCID: https://orcid.org/0000-0001-8779-316X)
- Maryam Faraji
Institutions
- Shahed University (IR)
- Qom Islamic Azad University (IR)
- Qom University of Medical Science and Health Services (IR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.bbrep.2025.101997
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94