The Disposition Index in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes
Little is known about the relationship between secretion and sensitivity in individuals at risk for type 1 diabetes (T1D). This study examined the relationship between secretion and sensitivity in antibody-positive relatives at risk for T1D and the predictive value of the disposition index (DI) as a measure of β-cell function. Secretion and sensitivity measures in two independent antibody-positive populations at risk for T1D had an inverse relationship across different glycemic ranges. The DI using different measures of secretion and sensitivity was predictive of T1D. The DI is a useful biomarker of β-cell function in individuals at risk for T1D.
Authors
- Antoinette Moran (ORCID: https://orcid.org/0000-0002-2694-5147)
- MARIA JOSE REDONDO (ORCID: https://orcid.org/0000-0001-5871-4645)
- Ingrid Libman (ORCID: https://orcid.org/0000-0002-0255-4555)
- Heba M. Ismail (ORCID: https://orcid.org/0000-0003-0102-0030)
- Jay M. Sosenko (ORCID: https://orcid.org/0000-0002-7204-8367)
- Kieren J. Mather (ORCID: https://orcid.org/0000-0001-8696-7500)
- Mark A. Atkinson (ORCID: https://orcid.org/0000-0001-8489-4782)
- Alessandra Petrelli (ORCID: https://orcid.org/0000-0002-5639-9415)
- Alfonso Galderisi (ORCID: https://orcid.org/0000-0001-8885-3056)
- David Cuthbertson
- Laura M. Jacobsen (ORCID: https://orcid.org/0000-0002-5144-7836)
- Tamara S. Hannon (ORCID: https://orcid.org/0000-0002-7523-5053)
Institutions
- University of Minnesota (US)
- University of Miami (US)
- Eli Lilly (United States) (US)
- University of Pittsburgh (US)
- Baylor College of Medicine (US)
- University of Milan (IT)
- University of South Florida (US)
- Yale University (US)
- University of Florida (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Indiana University (US)
Publication Details
- Journal
- Diabetes
- Published
- 2025-04-02
- DOI
- https://doi.org/10.2337/db24-1000
- Citations
- 3
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.45