Voluntary Exercise Attenuates Tumor Growth in a Preclinical Model of Castration-Resistant Prostate Cancer
Three weeks of voluntary wheel running was effective in delaying tumor formation and progression, which coincided with reduced transcription of DNA replication, AR signaling targets, and mitochondrial dynamics. We further identified a downregulation in molecular pathways related to angiogenesis that may be responsible for the delayed tumor formation and progression by voluntary wheel running.
Authors
- Benjamin A. Kugler (ORCID: https://orcid.org/0000-0003-0822-7106)
- Meaghan Anderson
- Susan Patalano-Salsman
- Kai Zou (ORCID: https://orcid.org/0000-0003-4164-7129)
- Mu‐Qing Li (ORCID: https://orcid.org/0000-0003-2254-0000)
- Paul Nguyen (ORCID: https://orcid.org/0000-0001-7998-293X)
- Changmeng Cai (ORCID: https://orcid.org/0000-0002-8701-2586)
- Nicolas Berger (ORCID: https://orcid.org/0000-0001-7276-5246)
- Songqi Zhang
- Jill A. Macoska (ORCID: https://orcid.org/0000-0001-8471-2221)
- Dong Han (ORCID: https://orcid.org/0000-0002-9074-6708)
Institutions
- University of Massachusetts Boston (US)
Publication Details
- Journal
- Medicine & Science in Sports & Exercise
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1249/mss.0000000000003712
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04