Baicalin n-butyl ester alleviates inflammatory bowel disease and inhibits pyroptosis through the ROS/ERK/P-ERK/NLRP3 pathway in vivo and in vitro
BNE protects against colitis by increasing the abundance of Lachnospiraceae in vivo and suppressing pyroptosis via binding ERK protein and inhibiting ROS/ERK/P-ERK/NLRP3 in vivo and in vitro.
Authors
- Zhichao Yu (ORCID: https://orcid.org/0000-0003-0197-1709)
- Mengru Guo
- Linlu Zhao (ORCID: https://orcid.org/0009-0008-6375-1836)
- Xiaoxi Liu (ORCID: https://orcid.org/0000-0002-4533-5221)
- Xingbin Ma (ORCID: https://orcid.org/0000-0003-2874-8312)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-8861-7336)
- Jieyi He
- Xianghong Ju (ORCID: https://orcid.org/0000-0001-8822-484X)
- Youquan Li
- Huining Wu
- Yin Yong
Institutions
- Guangdong Ocean University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.biopha.2025.118012
- Citations
- 9
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.25