Curcumin-mediated NRF2 induction limits inflammatory damage in, preclinical models of cystic fibrosis
This work highlights the protective role of NRF2 in limiting inflammation and injury and show that therapeutic strategies to normalize NRF2 activity, using curcumin or others NRF2 activators, might simultaneously reduce airway inflammation and damage in CF.
Authors
- Charlotte Bureau (ORCID: https://orcid.org/0000-0002-2095-6670)
- Laure Yatime (ORCID: https://orcid.org/0000-0002-3650-8012)
- Audrey Bernut (ORCID: https://orcid.org/0000-0002-1928-8329)
- Jean‐Louis Herrmann (ORCID: https://orcid.org/0000-0003-2347-6418)
- Stephen A. Renshaw (ORCID: https://orcid.org/0000-0003-1790-1641)
- Céline Cougoule (ORCID: https://orcid.org/0000-0002-6795-5448)
- R. Andres Floto
- Stephen Adonai Leon‐Icaza (ORCID: https://orcid.org/0000-0002-7546-8228)
- Maxence Frétaud (ORCID: https://orcid.org/0000-0003-1879-1333)
- Christelle Langevin (ORCID: https://orcid.org/0000-0002-6013-4460)
- Sarahdja Cornélie (ORCID: https://orcid.org/0009-0005-6674-0794)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- MRC Laboratory of Molecular Biology (GB)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université de Montpellier (FR)
- University of Cambridge (GB)
- Université Paris-Saclay (FR)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Institut de Pharmacologie et de Biologie Structurale (FR)
- Virologie et Immunologie Moléculaires (FR)
- Infection et inflammation (FR)
- University of Sheffield (GB)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.biopha.2025.117957
- Citations
- 6
- Primary Topic
- Curcumin's Biomedical Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.55