Striasteroids A–C, Three Hybrid Steroids with Neuraminidase Inhibitory Activities from a Marine-Derived <i>Striaticonidium cinctum</i>
Three unprecedented hybrid steroids, striasteroids A-C (<b>1</b>-<b>3</b>), together with a known analogue (<b>4</b>), were isolated from the fungus <i>Striaticonidium cinctum</i> SCSIO41432. Their structures were identified through spectroscopic data, X-ray crystallography, and electronic circular dichroism calculations. Compounds <b>1</b> and <b>2</b>, which feature a new 6/6/6/6/6/5 hexacyclic framework, are polyketide-steroid hybrids with an oxabicyclo[3.3.1]nonane-bridged system. Compound <b>3</b>, characterized as the first naturally occurring adenine-steroid hybrid, exhibited the most potent inhibitory activity against neuraminidase with an IC<sub>50</sub> value of 6.15 ± 1.15 μM.
Authors
- Lan Tang (ORCID: https://orcid.org/0000-0002-2345-0886)
- Chun Yang (ORCID: https://orcid.org/0000-0001-5813-0914)
- Xuefeng Zhou (ORCID: https://orcid.org/0000-0001-9601-4869)
- Jian Cai (ORCID: https://orcid.org/0000-0001-7987-3338)
- Huaming Tao (ORCID: https://orcid.org/0000-0002-4799-1345)
- Yonghong Liu (ORCID: https://orcid.org/0000-0001-8327-3108)
- Chunmei Chen (ORCID: https://orcid.org/0000-0002-2949-7343)
Institutions
- Chinese Academy of Sciences (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- University of Chinese Academy of Sciences (CN)
- State Key Laboratory of Tropical Oceanography
- Southern Medical University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1021/acs.orglett.5c00901
- Citations
- 2
- Primary Topic
- Marine Sponges and Natural Products
- Type
- article
- Field-Weighted Citation Impact
- 2.47
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China