Chronotherapy With Once-Daily Osilodrostat Improves Cortisol Rhythm, Quality of Life, and Sleep in Cushing's Syndrome
Once-daily osilodrostat effectively and safely treats patients with biochemically controlled CS, improving circadian cortisol profiles, quality of life, and sleep. Findings support further exploration of chronotherapy-based approaches in CS management.
Authors
- Dario De Alcubierre (ORCID: https://orcid.org/0000-0001-5242-1761)
- Ilaria Bonaventura (ORCID: https://orcid.org/0000-0002-9333-5189)
- Marianna Minnetti (ORCID: https://orcid.org/0000-0002-9091-2809)
- Daniele Gianfrilli (ORCID: https://orcid.org/0000-0002-2682-8266)
- Nicola Di Paola (ORCID: https://orcid.org/0009-0008-9947-6522)
- Mary Anna Venneri (ORCID: https://orcid.org/0000-0002-0687-8135)
- Alessandra Tomaselli (ORCID: https://orcid.org/0000-0003-1277-9640)
- Rosario Pivonello (ORCID: https://orcid.org/0000-0002-9632-1348)
- Valeria Hasenmajer (ORCID: https://orcid.org/0000-0003-4301-6662)
- Francesca Sciarra (ORCID: https://orcid.org/0000-0001-9492-296X)
- Chiara Simeoli
- Flavio Rizzo (ORCID: https://orcid.org/0000-0003-2191-3311)
- Emilia Sbardella (ORCID: https://orcid.org/0000-0002-2220-9783)
- Lorenzo Cerroni
- Davide Ferrari (ORCID: https://orcid.org/0009-0004-3803-4350)
- Andrea Maria Isidori (ORCID: https://orcid.org/0000-0002-9037-5417)
- Ludovica Vincenzi
- Riccardo Pofi
Institutions
- Policlinico Umberto I (IT)
- Churchill Hospital (GB)
- University of Oxford (GB)
- Oxford Biomedical Research (US)
- Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (IT)
- Oxford Centre for Diabetes, Endocrinology and Metabolism (GB)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1210/clinem/dgaf206
- Citations
- 18
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 23.31