Thiol-Epoxy Click Chemistry: The Synthesis of Vicinal Amino Alcohols Containing a 1,2,4-Triazole Ring
As examples of “Click Chemistry”, the reaction of 1-(oxiran-2-ylmethyl)piperidine with several 1,2,4-triazoles derivatives was studied. As a result, the reaction shows that the oxirane ring opens regiospecifically, according to Krasusky’s rule, without using a catalyst. The basic nitrogen present in 1-(oxiran-2-ylmethyl)piperidine has a catalytic (anchimer) effect.
Authors
- A. S. Galstyan (ORCID: https://orcid.org/0000-0003-3507-8230)
- Tariel V. Ghochikyan (ORCID: https://orcid.org/0009-0008-4417-0462)
- Astghik A. Shahkhatuni (ORCID: https://orcid.org/0000-0003-1848-5256)
- K. S. Avetisyan (ORCID: https://orcid.org/0000-0002-8805-7575)
- Andranik M. Davinyan (ORCID: https://orcid.org/0009-0000-9630-5455)
- M. A. Samvelyan (ORCID: https://orcid.org/0000-0001-9201-8395)
- Valentine G. Nenajdenko (ORCID: https://orcid.org/0000-0001-9162-5169)
- Artyom V. Petrosyan (ORCID: https://orcid.org/0009-0003-3149-0241)
Institutions
- Yerevan State University (AM)
- Lomonosov Moscow State University (RU)
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Chemistry
- Published
- 2025-04-01
- DOI
- https://doi.org/10.3390/chemistry7020053
- Citations
- 2
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.87