Thioester-containing protein TEP15 promotes malaria parasite development in mosquitoes through negative regulation of melanization
We describe a mosquito TEP that negatively regulates immunity, further enriching the functional diversity of TEP family members. In addition, our results suggest that oocysts may exploit TEPs to escape or inhibit mosquito immunity, highlighting potential targets for blocking malaria transmission.
Authors
- Jianyong Li (ORCID: https://orcid.org/0000-0002-5878-945X)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-4966-2086)
- Feng Zhu (ORCID: https://orcid.org/0000-0003-4845-109X)
- Xin Qin (ORCID: https://orcid.org/0000-0002-2643-7927)
Institutions
- Army Medical University (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s13071-025-06772-5
- Citations
- 3
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China