Clinical application of polar body-based preimplantation genetic testing for maternal mutations in women with a limited number of oocytes
The PB-based strategy is feasible and effective for determining the mutation-carrier statuses of embryos in PGT-M for maternal mutations. Compared to blastocyst stage detection, this method may save a greater number of genetically unaffected embryos for patients. Further clinical trials are needed to determine whether PB biopsy is more beneficial than TE cell biopsy for women with disease-causing mutations and a limited number of oocytes in PGT-M.
Authors
- Xingwu Wu
- Tao Ding (ORCID: https://orcid.org/0009-0001-9808-0912)
- Zengming Li (ORCID: https://orcid.org/0009-0007-3808-1255)
- Lifeng Tian (ORCID: https://orcid.org/0009-0003-3797-3674)
- Jialyu Huang (ORCID: https://orcid.org/0000-0002-2629-3986)
- Jia Chen (ORCID: https://orcid.org/0009-0002-3211-1437)
- Ziyu Zhang (ORCID: https://orcid.org/0000-0002-3621-1817)
- Qiongfang Wu (ORCID: https://orcid.org/0000-0002-8432-7240)
- Ranhui Duan (ORCID: https://orcid.org/0000-0001-7117-4487)
- Ge Chen (ORCID: https://orcid.org/0000-0002-0501-372X)
- Yanqiu Liu (ORCID: https://orcid.org/0000-0002-6123-5618)
- Yongyi Zou (ORCID: https://orcid.org/0000-0001-5869-7988)
- Yan Zhao (ORCID: https://orcid.org/0009-0000-3608-3715)
- Qiang Xu (ORCID: https://orcid.org/0000-0003-1797-6256)
- Houyang Chen (ORCID: https://orcid.org/0000-0002-1906-5619)
Institutions
- Central South University (CN)
- Jiangxi Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Orphanet Journal of Rare Diseases
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1186/s13023-025-03659-7
- Citations
- 1
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province