Graded response of the pulmonary circulation to progressive pulmonary embolism in sheep: From compensation to lethal right heart failure
Compensatory increases in RV contractility initially maintain CO in PE despite RV afterload elevation. Increased RV contractility eventually fails to compensate for elevated RV afterload, causing RV-PA uncoupling in severe PE with RHF. Severe PE rapidly progresses to lethal RHF and will likely require immediate intervention to prevent death.
Authors
- Cherry Ballard‐Croft (ORCID: https://orcid.org/0000-0003-3639-7049)
- Kristine R. Polley (ORCID: https://orcid.org/0009-0003-6893-2031)
- Cheng Zhou (ORCID: https://orcid.org/0000-0002-4091-4777)
- Joseph B. Zwischenberger (ORCID: https://orcid.org/0000-0001-6812-2571)
- Yuman Li (ORCID: https://orcid.org/0000-0002-4388-8199)
- Masashi Kawabori (ORCID: https://orcid.org/0000-0002-3580-5664)
- Dongfang Wang (ORCID: https://orcid.org/0000-0003-3449-3811)
- Keshava Rajagopal (ORCID: https://orcid.org/0000-0001-9352-1259)
Institutions
- University of Kentucky (US)
- Thomas Jefferson University (US)
Publication Details
- Journal
- JHLT Open
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.jhlto.2025.100260
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Abiomed