A Photo-Controllable DNAzyme-Based Nanosensor for miRNA Imaging in Living Cells
MircroRNA (miRNA) exhibits abnormal expression in many cancer diseases, and the detection and analysis of miRNA are significant for the early diagnosis of diseases and research on miRNA functions. In this work, we construct a UV-triggered DNAzyme (UTD) nanosensor for the early detection of miRNA in tumor cells. As the nanodevice was delivered into cells and irradiated by UV light, the controllable imaging of miRNA in living cells was achieved. This method effectively avoids false signal issues, providing a new strategy for high-spatiotemporal-resolution imaging of miRNA in living cells.
Authors
- Si‐Yang Liu (ORCID: https://orcid.org/0000-0001-8377-2396)
- Zong Dai (ORCID: https://orcid.org/0000-0002-3646-7396)
- Yanfei Zhang (ORCID: https://orcid.org/0000-0001-7811-6597)
- Shujun J. Zhang (ORCID: https://orcid.org/0000-0001-6139-6887)
- Rui-Ning Ouyang (ORCID: https://orcid.org/0009-0009-7901-5769)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Chemosensors
- Published
- 2025-04-02
- DOI
- https://doi.org/10.3390/chemosensors13040123
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Guangzhou Municipal Science and Technology Project
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province