Autistic-like behaviors and impaired chronic inflammatory pain in primary nociceptive neuron-specific deletion of Mecp2 or Fmr1 knockout male mice
Absent Mecp2 or Fmr1 in primary nociceptive neurons plays role in the pathogenesis of ASD and that their expression in primary nociceptors is crucial for the maintenance of chronic inflammatory pain by reducing neuroinflammation and CGRP expression in the peripheral and central nervous systems.
Authors
- Na Chang (ORCID: https://orcid.org/0000-0002-2755-7373)
- Yinwei Zhou (ORCID: https://orcid.org/0009-0008-7818-7967)
- Peng-Bo Jing (ORCID: https://orcid.org/0009-0003-0065-4506)
- Feng‐Ming Zhang
- Jia-Yi Ge
- Lin Luo (ORCID: https://orcid.org/0000-0002-7680-3518)
- Xiaohua Cao (ORCID: https://orcid.org/0000-0001-5207-6400)
- Xing‐Jun Liu (ORCID: https://orcid.org/0000-0002-5496-541X)
- Jiani Wu (ORCID: https://orcid.org/0000-0003-4954-0692)
- Jiahuan Xu
- Xiang Zhou (ORCID: https://orcid.org/0000-0002-4904-4245)
Institutions
- Nantong University (CN)
Publication Details
- Journal
- Behavioural Brain Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.bbr.2025.115570
- Citations
- 3
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.45