Neuroprotective effects of bone marrow mesenchymal stem cells combined with mannitol on radiation-induced brain injury by regulating autophagy via the PI3K/AKT/mTOR signaling pathway
The combination of BMSCs and mannitol treatment significantly improved cognitive function and hippocampal neuronal survival in RIBI rats. This effect was achieved by increasing BBB permeability, facilitating BMSCs migration to the injured region, and regulating excessive autophagy through the PI3K/AKT/mTOR pathway. This combined treatment demonstrated a neuroprotective effect superior to that of BMSCs treatment alone.
Authors
- Xu Tong (ORCID: https://orcid.org/0009-0000-4258-1024)
- Zhanhong Liu (ORCID: https://orcid.org/0000-0003-1844-004X)
- Yuxin Wen (ORCID: https://orcid.org/0000-0002-2352-5622)
- Xia Tong
- Na Zhang (ORCID: https://orcid.org/0000-0001-9510-4520)
- Shichao Pan
- Song Xue (ORCID: https://orcid.org/0000-0003-1934-6215)
- Kaina Xu
- Ye Teng
Institutions
- Affiliated Hospital of Hebei University (CN)
- Nanchong Central Hospital (CN)
- Qiqihar Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111326
- Citations
- 3
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56