Unraveling the role of HIF-1α in allergic rhinitis: A key regulator of epithelial barrier integrity via PI3K pathway
HIF-1α aggravates AR by promoting inflammation, mucosal remodeling, and epithelial barrier dysfunction via PI3K pathway activation. This finding not only enriches our understanding of AR pathophysiology but also highlights HIF-1α and its downstream signaling pathways as prospective therapeutic targets for AR.
Authors
- G Zhang (ORCID: https://orcid.org/0009-0008-8844-5544)
- Ming Xi Tang (ORCID: https://orcid.org/0000-0003-1179-2624)
- Lei He (ORCID: https://orcid.org/0009-0001-4410-9038)
- Yongbo Zhang (ORCID: https://orcid.org/0000-0003-0005-4861)
- Chungen Zhou (ORCID: https://orcid.org/0000-0002-1008-0572)
- Zhuo Wu (ORCID: https://orcid.org/0009-0006-0165-8746)
Institutions
- Ningbo University (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1016/j.tice.2025.102898
- Citations
- 3
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Medical Science and Technology Project of Zhejiang Province