DIAGNOSTIC AND THERAPEUTIC CHALLENGES IN ELDERLY-ONSET SJÖGREN’S SYNDROME

Recent research indicates that the age of disease onset plays a crucial role in shaping the phenotype of systemic autoimmune inflammatory diseases. Late-onset Sjögren’s syndrome (SS) presents unique diagnostic challenges due to symptom overlap with age-related conditions. Key issues include difficulties in interpreting tests for sicca syndrome, high prevalence of comorbidities, polypharmacy, and underutilization of salivary gland biopsy in older patients. This narrative review provides an overview of the clinical and immunological characteristics of late-onset SS, along with management strategies tailored to this population. Emphasis is placed on the need for an age-adjusted diagnostic approach and the value of multidisciplinary, holistic care for late-onset SS patients.