Antiseizure potential of the triple T‐type calcium channel blocker <scp>ACT</scp> ‐709478 (apinocaltamide) in rodent models
Based on its efficacy profile in rodent models, ACT-709478 represents a promising drug candidate for the treatment of absence epilepsy such as childhood absence epilepsy or syndromes featuring SWDs. It could possibly also be beneficial for epileptic syndromes presenting with additional seizure types.
Authors
- Catherine Roch (ORCID: https://orcid.org/0000-0002-0260-2756)
- Corinne Roucard
- Michel A. Steiner (ORCID: https://orcid.org/0000-0001-9923-6555)
- Melanie Keßler (ORCID: https://orcid.org/0009-0005-3577-7869)
- Hélène Roellinger
Institutions
- Idorsia (Switzerland) (CH)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/epi.18386
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00