A Viroimmunologic Model to Characterize the Antiviral Effect of Molnupiravir in Outpatients Infected With SARS-CoV-2: Implication for Treatment Duration
Our model suggests that molnupiravir acts primarily on viral replication, and not specifically on viral infectivity. Longer administration of molnupiravir may reduce the rebound rate, shortening the time to viral clearance.
Authors
- Bach Nguyen (ORCID: https://orcid.org/0000-0003-0098-1833)
- Paul Little (ORCID: https://orcid.org/0000-0003-3664-1873)
- David M. Lowe (ORCID: https://orcid.org/0000-0001-6102-2375)
- Ly‐Mee Yu (ORCID: https://orcid.org/0000-0003-0331-7364)
- Joseph Frank Standing (ORCID: https://orcid.org/0000-0002-4561-7173)
- Judith Breuer (ORCID: https://orcid.org/0000-0001-8246-0534)
- Christopher Butler (ORCID: https://orcid.org/0000-0002-0102-3453)
- Jérémie Guedj (ORCID: https://orcid.org/0000-0002-5534-5482)
- Akosua Adom Agyeman (ORCID: https://orcid.org/0000-0002-8866-3524)
- Shengyuan Zhang (ORCID: https://orcid.org/0009-0002-8741-8567)
- Victoria Harris (ORCID: https://orcid.org/0000-0002-3345-2826)
- Julie Bertrand (ORCID: https://orcid.org/0000-0002-6568-1041)
Institutions
- Inserm (FR)
- Royal Free London NHS Foundation Trust (GB)
- Université Paris Cité (FR)
- Great Ormond Street Hospital (GB)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- NIHR Southampton Biomedical Research Centre (GB)
- Institute of Infection and Immunity (CA)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/infdis/jiaf158
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79