Intracranial stimulation for pediatric refractory epilepsy: A single institutional experience using evolving therapies
This study investigates the use of various neurostimulation therapies for treating pediatric refractory epilepsy (PRE) including deep brain stimulation (DBS), responsive neurostimulation (RNS), and chronic subthreshold stimulation (CSS). Overall, neuromodulation was found to be effective in reducing seizures in most patients, with 59% of patients showing at least a 50% reduction in seizure frequency. Additionally, the treatments were generally safe, with few complications and no instances of permanent deficits.
Authors
- Rohin Singh (ORCID: https://orcid.org/0000-0001-5258-507X)
- Panagiotis Kerezoudis (ORCID: https://orcid.org/0000-0002-3590-6289)
- Jamie J. Van Gompel (ORCID: https://orcid.org/0000-0001-8087-7870)
- Jonathon J. Parker (ORCID: https://orcid.org/0000-0002-0531-8400)
- Kai J. Miller (ORCID: https://orcid.org/0000-0002-6687-6422)
- Sanjeet S. Grewal (ORCID: https://orcid.org/0000-0002-4307-7062)
- Keith Starnes (ORCID: https://orcid.org/0000-0002-9111-4243)
- Brian N. Lundstrom (ORCID: https://orcid.org/0000-0002-5310-5549)
- Megan M. J. Bauman (ORCID: https://orcid.org/0000-0003-1910-6617)
- Karimul Islam (ORCID: https://orcid.org/0000-0001-6118-1202)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
- University of Rochester (US)
Publication Details
- Journal
- Epilepsia Open
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/epi4.70006
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47